a simulation study of calcium release channel

نویسندگان

m. monajjemi

h.h. haeri

s.m. hashemianzadeh

m. gholami

k. zare

چکیده

the ip3r calcium release channel has been simulated using a stochastic simulation algorithm (ssa;gillespie algorithm) and de young-keiser model. a set of different concentration for cat' and ip3 havebeen used. considering the number of molecules in each state, a non linear behavior of the system can beseen clearly. the inhibiting role of the ca+2 on the open state (x110) has been studied. the degree ofinhibition may depend on the ip3 concentration. different levels of inhibition have seen in differentinhibited states. using the gillespie algorithm, the frequency graphs for each set of ca+2 and ip3concentrations and in different time domains can be achieved. the probability of open channel increaseswith going from small time domain to large time domain. a good consistency can be inferred comparingwith different results from the past studies (both in theoretical and experimental studies).a reaction patternin fast time domain has seen, too.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

A simulation study of calcium release channel

The IP3R calcium release channel has been simulated using a stochastic simulation algorithm (SSA;Gillespie algorithm) and De young-Keiser model. A set of different concentration for Cat' and IP3 havebeen used. Considering the Number of molecules in each state, a non linear behavior of the system can beseen clearly. The inhibiting role of the Ca+2 on the open state (X110) has been studied. The d...

متن کامل

a study on thermodynamic models for simulation of 1,3 butadiene purification columns

attempts have been made to study the thermodynamic behavior of 1,3 butadiene purification columns with the aim of retrofitting those columns to more energy efficient separation schemes. 1,3 butadiene is purified in two columns in series through being separated from methyl acetylene and 1,2 butadiene in the first and second column respectively. comparisons have been made among different therm...

Evaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

متن کامل

Evaluation of Mutagenicity of Mebudipine, a New Calcium Channel Blocker

Mebudipine is a new dihydropyridine calcium channel blocker, synthesized in our laboratory, for treatment of hypertension. It has shown a better efficacy than other drugs in this group. For assessing the risks of this drug, certain safety tests in the preclinical stage have been performed. In this study mutagenic effect of mebudipine was evaluated using Ames assay that could assess the mutageni...

متن کامل

a study of translation of english litrary terms into persian

چکیده هدف از پژوهش حاضر بررسی ترجمه ی واژه های تخصصی حوزه ی ادبیات به منظور کاوش در زمینه ی ترجمه پذیری آنها و نیز راهکار های به کار رفته توسط سه مترجم فارسی زبان :سیامک بابایی(1386)، سیما داد(1378)،و سعید سبزیان(1384) است. هدف دیگر این مطالعه تحقیق در مورد روش های واژه سازی به کار رفته در ارائه معادل های فارسی واژه های ادبی می باشد. در راستای این اهداف،چارچوب نظری این پژوهش راهکارهای ترجمه ار...

15 صفحه اول

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
journal of physical & theoretical chemistry

ISSN

دوره 2

شماره 3 2005

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023